Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal bone remodelling in inflammatory arthritis

E R Bogoch1, E Moran

  • 1Orthopaedic Research Laboratory, St. Michael's Hospital, Wellesley Central Site, University of Toronto, Ont.

Canadian Journal of Surgery. Journal Canadien De Chirurgie
|August 26, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comments to Reply to "Differences in Molecular Sensitization Profiles Between Spanish and Latin American Mite-Allergic Patients".

Journal of investigational allergology & clinical immunology·2025
Same author

Differences in Molecular Sensitization Profiles Between Spanish and Latin American Mite-Allergic Patients.

Journal of investigational allergology & clinical immunology·2024
Same author

A census of general surgery consultants in England and Wales: implications for the current and future surgical workforce.

Annals of the Royal College of Surgeons of England·2023
Same author

Fragility fracture patients with a history of prior fractures more likely to present with multiple risk factors: findings from a province-wide fracture liaison service.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

Ventral Approach for the Non-transecting Bulbar Urethroplasty.

Urology·2021
Same author

Evolution of male patients with detrusor underactivity and conservative treatment. Five-year follow-up.

Actas urologicas espanolas·2020
Same journal

Trends in the incidence and surgical treatment of hepatocellular carcinoma in Ontario.

Canadian journal of surgery. Journal canadien de chirurgie·2026
Same journal

Referral patterns and wait times in complex peripheral nerve injuries: a review of a multidisciplinary clinic in Canada.

Canadian journal of surgery. Journal canadien de chirurgie·2026
Same journal

Cost of hospital admission after autologous breast reconstruction and factors associated with increased cost: a population-based cohort study.

Canadian journal of surgery. Journal canadien de chirurgie·2026
Same journal

Outpatient surgical referrals from primary care providers for people experiencing homelessness: a retrospective review.

Canadian journal of surgery. Journal canadien de chirurgie·2026
Same journal

Management of cystic echinococcosis in British Columbia: outcomes and suggestions to improve guideline adherence.

Canadian journal of surgery. Journal canadien de chirurgie·2026
Same journal

Practical solutions for complex surgical problems: right operation, right place, right time: General Surgery Atlantic Conference 2026, May 22-24, 2026, Fox Harb'r Resort, Fox Harbour, Nova Scotia.

Canadian journal of surgery. Journal canadien de chirurgie·2026
See all related articles

Rheumatoid arthritis causes osteopenia and bone loss through increased osteoclast activity. Bisphosphonates, by inhibiting osteoclasts, show potential in treating bone loss and joint damage in rheumatoid arthritis.

Area of Science:

  • Rheumatology
  • Orthopedics
  • Cell Biology

Background:

  • Osteopenia is a significant comorbidity in rheumatoid arthritis (RA), impacting joint disease management.
  • Inflammatory arthritis in animal models shows increased bone remodeling and altered bone microstructure.
  • Subchondral bone plate and cortical bone are weakened by vascular invasion and large resorption defects in RA models.

Purpose of the Study:

  • To investigate the role of osteoclast activity in RA-induced bone loss.
  • To evaluate the potential of bisphosphonates in managing osteopenia and joint damage in RA.

Main Methods:

  • Review of animal models of inflammatory arthritis-induced bone loss.
  • Analysis of biomechanical tests and mathematical models of bone strength.

Related Experiment Videos

  • Examination of osteoclast number and activity in RA and animal models.
  • Assessment of bisphosphonate efficacy in preclinical studies.

    • Main Results:

    • Large cortical resorption defects, exceeding normal osteonal remodeling, are primary contributors to bone strength loss in experimental RA.
    • Osteoclast number and activity are elevated in RA and its animal models.
    • Bisphosphonates experimentally reduce osteopenia, prevent bone strength loss, and protect articular cartilage.

    Conclusions:

    • Bisphosphonates demonstrate potential for prophylaxis and treatment of osteopenia and joint damage in inflammatory arthritis.
    • Chondroprotection by bisphosphonates may involve inhibiting osteoclast-mediated subchondral bone resorption and altering bone marrow cell distribution.
    • Bisphosphonates, already used for other bone diseases, could be valuable in managing RA complications.