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Mathemycin A, a new antifungal macrolactone from Actinomycete sp. HIL Y-8620959. II. Structure elucidation

T Mukhopadhyay1, E K Vijayakumar, S R Nadkarni

  • 1Hoechst Marion Roussel Limited, Mumbai, India.

The Journal of Antibiotics
|August 26, 1998
PubMed
Abstract

No abstract available in PubMed .

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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