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Related Experiment Videos

Bacillus cereus-induced malabsorption in young mice

D S Madge

    Digestion
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Bacillus cereus infection impaired intestinal absorption of nutrients like D-glucose in young mice. This malabsorption was dose- and time-dependent, affecting the small intestine, but not in older mice.

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    Area of Science:

    • Microbiology
    • Gastroenterology
    • Nutritional Science

    Background:

    • Bacillus cereus is a common bacterium with potential effects on host physiology.
    • Intestinal absorption is crucial for nutrient uptake and overall health.
    • Understanding the impact of bacterial infections on nutrient absorption is vital for public health.

    Purpose of the Study:

    • To investigate the effect of Bacillus cereus oral administration on intestinal absorption in mice.
    • To determine if the observed malabsorption is dose- and time-dependent.
    • To assess the impact on different nutrients and fluid transfer along the small intestine.

    Main Methods:

    • Oral administration of Bacillus cereus to young and old mice.
    • In vitro measurement of intestinal absorption of various solutes (D-glucose, D-galactose, L-arginine, L-histidine, L-ornithine, L-proline).

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  • Assessment of dose- and time-dependency, location of impairment, and fluid transfer.

    • Main Results:

    • A single oral dose of Bacillus cereus decreased in vitro intestinal absorption of D-glucose, D-galactose, L-arginine, L-histidine, L-ornithine, and L-proline in young mice.
    • D-glucose malabsorption was dose- and time-dependent and occurred throughout the small intestine, particularly distally.
    • Intestinal absorption and fluid transfer were largely unaffected in older infected mice, and histological changes were minimal.

    Conclusions:

    • Bacillus cereus infection leads to significant malabsorption of key nutrients in young mice.
    • The effects are specific to younger animals and suggest a localized impact on intestinal transport mechanisms.
    • Further research is needed to elucidate the precise mechanisms and long-term consequences.