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Related Experiment Videos

Effects of PEEP on systemic venous capacitance

B Lambermont1, O Detry, V D'Orio

  • 1Experimental Hemodynamics Laboratory (HemoLiège), University of Liège, Belgium.

Archives of Physiology and Biochemistry
|August 26, 1998
PubMed
Summary

Positive end-expiratory pressure (PEEP) reduces venous compliance and increases peripheral blood pooling. This impedes venous return, decreasing cardiac output due to reduced preload.

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Area of Science:

  • Physiology
  • Cardiovascular System
  • Respiratory System

Background:

  • Positive end-expiratory pressure (PEEP) is used in mechanical ventilation.
  • Its effects on peripheral venous capacitance and central hemodynamics require further elucidation.

Purpose of the Study:

  • To determine the effects of PEEP on peripheral venous capacitance.
  • To relate these changes to central hemodynamic disturbances.

Main Methods:

  • Studied venous volume-pressure (V/P) relationships in 6 anesthetized pigs.
  • Assessed systemic venous compliance and unstressed volume.
  • Measured cardiac volumes and blood volume partitioning using thermo-dye dilution techniques.

Main Results:

Related Experiment Videos

  • PEEP application (15 cm H2O) reduced venous compliance by 48%.
  • Unstressed volume increased by 25%, with peripheral blood pooling rising from 63% to 74%.
  • Left heart and right ventricular end-diastolic volumes decreased by 8% and 44%, respectively.

Conclusions:

  • Increased venous unstressed volume and reduced compliance due to PEEP impede venous return.
  • This leads to decreased cardiac output secondary to reduced preload.