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Obsessive-compulsive disorder in post-streptococcal infection

E Monasterio¹, R T Mulder, T D Marshall

¹Department of Psychological Medicine, Christchurch School of Medicine, New Zealand.

The Australian and New Zealand Journal of Psychiatry

|August 26, 1998

Summary

This summary is machine-generated.

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See all related articles

Sudden obsessive-compulsive symptoms appeared after a streptococcal infection. Treatment with fluoxetine led to symptom improvement, suggesting an autoimmune link.

Area of Science:

Neuroscience
Infectious Diseases
Immunology

Background:

Obsessive-compulsive disorder (OCD) can have various triggers.
Infections are increasingly recognized as potential contributors to neuropsychiatric conditions.

Observation:

A 35-year-old woman developed new-onset obsessive-compulsive symptoms.
Symptoms emerged two weeks post-peritoneal infection with alpha-haemolytic streptococci.
The patient had no prior history of OCD or family history.

Findings:

The patient was treated with daily fluoxetine (80 mg).
A progressive reduction in obsessive-compulsive symptoms was observed.
This indicates a positive response to selective serotonin reuptake inhibitor (SSRI) therapy.

Related Experiment Videos

Implications:

The findings suggest a potential autoimmune response to streptococcal infection as a cause of OCD.
This case highlights the importance of considering infectious triggers in OCD etiology.
Further research into the autoimmune mechanisms linking infections and OCD is warranted.