Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Laser light scattering immunoassay: an improved data analysis by CONTIN method

T Antony¹, A Saxena, K B Roy

¹School of Physical Sciences, Centre for Biotechnology, Jawaharlal Nehru University, New Delhi, India.

Journal of Biochemical and Biophysical Methods

|August 26, 1998

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrating Direct Observation of Procedural Skills as a workplace‑based assessment tool for residents working in an intensive care unit.

African journal of thoracic and critical care medicine·2026

Same author

Radiometer calibration using machine learning.

Scientific reports·2025

Same author

Radiation exposure due to radon, thoron and their progeny in different types of dwellings in two districts of Meghalaya, India.

Isotopes in environmental and health studies·2025

Same author

Topological transitions, pinning and ratchets for driven magnetic hopfions in nanostructures.

Scientific reports·2025

Same author

Effect of carnitine on Hariana bull spermatozoa function after cryopreservation.

Cryo letters·2025

Same author

Fortification of semen extender with mifepristone improves the cryo-survival of cattle spermatozoa.

Cryo letters·2025

Same journal

Proceedings of the 12th International Symposium Of Chemistry, Miercurea Ciuc (Csíkszereda), Romania, October 5-8, 2006; and proceedings of the 7th International Symposium and Summer School on Bioanalysis, Pécs, Hungary, June 10-17, 2007.

Journal of biochemical and biophysical methods·2008

Same journal

12th International Symposium Of Chemistry, Miercurea Ciuc (Csíkszereda), Romania, 5th to 8th of October, 2006. 7th International Symposium and Summer School on Bioanalysis, Pécs, Hungary, 10th to 17th of June, 2007.

Journal of biochemical and biophysical methods·2008

Same journal

Optimized HPLC method for tramadol and O-desmethyl tramadol determination in human plasma.

Journal of biochemical and biophysical methods·2008

Same journal

The alternating current polarographic behavior and determination of lansoprazole and omeprazole in dosage forms and biological fluids.

Journal of biochemical and biophysical methods·2008

Same journal

Continuous-flow complete-mixing system for assessing the effects of environmental factors on colony-level coral metabolism.

Journal of biochemical and biophysical methods·2008

Same journal

Utilization of fluorescence tracer in hyperinsulinemic-euglycemic clamp test in mice.

Journal of biochemical and biophysical methods·2008

See all related articles

This study demonstrates laser light scattering immunoassay (LIA) for detecting malaria antibodies. The method effectively monitors particle agglutination using dynamic light scattering (DLS), offering superior data analysis for diagnostics.

Area of Science:

Biomedical diagnostics
Immunology
Parasitology

Background:

Antibody detection is crucial for diagnosing infectious diseases like malaria.
Conventional diagnostic methods may have limitations in sensitivity or specificity.

Purpose of the Study:

To evaluate the efficacy of laser light scattering immunoassay (LIA) for detecting antibodies against Plasmodium falciparum.
To explore the advantages of dynamic light scattering (DLS) and CONTIN data analysis in immunoassay applications.

Main Methods:

Laser light scattering immunoassay (LIA) was employed.
Dynamic light scattering (DLS) was used as the detection probe.
Data analysis was performed using the CONTIN method.

Main Results:

Related Experiment Videos

The LIA method successfully detected antibodies to P. falciparum.
Distribution analysis of DLS data provided superior insights compared to conventional interpretations (mean diffusion coefficient or hydrodynamic radius).

Conclusions:

Laser light scattering immunoassay (LIA) is a viable and effective method for detecting malaria-specific antibodies.
Advanced data analysis techniques like CONTIN enhance the diagnostic power of LIA.