Monoclonal antibodies to P-glycoprotein: preparation and applications to basic and clinical research

P-Glycoprotein, a member of the ABC transporter group, plays an important role in anticancer drug resistance. Many monoclonal antibodies to P-glycoprotein have been developed and used to study the molecular and cellular functions of P-glycoprotein. These monoclonal antibodies were used for gene cloning, purification and reconstitution of P-glycoprotein, analysis of transport functions of P-glycoprotein, immunological detection and selective killing of tumors that express P-glycoprotein for diagnostic, and therapeutic purposes.