Construction of MDR1 vectors for gene therapy

Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol.

The Journal of biological chemistry·1992

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.

The Journal of biological chemistry·1992

Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells.

Blood·1992

Alanine scanning mutagenesis identifies surface amino acids on domain II of Pseudomonas exotoxin required for cytotoxicity, proper folding, and secretion into periplasm.

The Journal of biological chemistry·1992

Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia.

Blood·1992

Transfer and expression of the human multiple drug resistance gene into live mice.

Proceedings of the National Academy of Sciences of the United States of America·1992

Clinical Europium fluorescent based lectin assays for mucin O-glycomics.

Methods in enzymology·2026

A dual-color FRET assay for detection and quantitative analysis of O-glycopeptidases.

Methods in enzymology·2026

Evolutionary genetic approaches to analyze mucins.

Methods in enzymology·2026

Ex vivo imaging and enzymatic analysis of intestinal mucus.

Methods in enzymology·2026

Glyco-TRAPP: A real-time glycocalyx permeability assay for assessing transmembrane mucin barrier function in live and fixed tissues.

Methods in enzymology·2026

Quantitative imaging approaches to capture structural and functional dynamics of colonic mucus in health and disease in situ.

Methods in enzymology·2026

New-Onset Raynaud Phenomenon during Ropeginterferon Alfa-2b Therapy for Polycythemia Vera: A Case Report and Review of the Literature.

Case reports in oncology·2026

131I-labeled engineered hybrid cell membrane biomimetic nanocarrier targets gastric cancer and enhances radioimmunotherapy.

Materials today. Bio·2026

Plant-Derived Extracellular Vesicles Delivered by Microinfusion Microneedling for Androgenetic Alopecia: A Retrospective Case Series.

Skin appendage disorders·2026

Erratum: Brem EA, Shieh K, Juarez D, et al. A phase 1 study adding pitavastatin to venetoclax therapy in AML and CLL/SLL: a mechanism-based drug repurposing strategy. Blood Neoplasia. 2024;1(4):100036.

Blood neoplasia·2026

Machine learning driven precision medicine in tacrolimus dosing: current research and future perspectives in liver and kidney transplantation.

Frontiers in immunology·2026

Modular engineered outer membrane vesicles for synergistic cancer immunotherapy via PD-L1 blockade and epigenetic reprogramming.

Frontiers in immunology·2026

Related Experiment Videos

Construction of MDR1 vectors for gene therapy

Related Concept Videos

Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol.

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.

Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells.

Alanine scanning mutagenesis identifies surface amino acids on domain II of Pseudomonas exotoxin required for cytotoxicity, proper folding, and secretion into periplasm.

Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia.

Transfer and expression of the human multiple drug resistance gene into live mice.

Clinical Europium fluorescent based lectin assays for mucin O-glycomics.

A dual-color FRET assay for detection and quantitative analysis of O-glycopeptidases.

Evolutionary genetic approaches to analyze mucins.

Ex vivo imaging and enzymatic analysis of intestinal mucus.

Glyco-TRAPP: A real-time glycocalyx permeability assay for assessing transmembrane mucin barrier function in live and fixed tissues.

Quantitative imaging approaches to capture structural and functional dynamics of colonic mucus in health and disease in situ.

New-Onset Raynaud Phenomenon during Ropeginterferon Alfa-2b Therapy for Polycythemia Vera: A Case Report and Review of the Literature.

131I-labeled engineered hybrid cell membrane biomimetic nanocarrier targets gastric cancer and enhances radioimmunotherapy.

Plant-Derived Extracellular Vesicles Delivered by Microinfusion Microneedling for Androgenetic Alopecia: A Retrospective Case Series.

Erratum: Brem EA, Shieh K, Juarez D, et al. A phase 1 study adding pitavastatin to venetoclax therapy in AML and CLL/SLL: a mechanism-based drug repurposing strategy. Blood Neoplasia. 2024;1(4):100036.

Machine learning driven precision medicine in tacrolimus dosing: current research and future perspectives in liver and kidney transplantation.

Modular engineered outer membrane vesicles for synergistic cancer immunotherapy via PD-L1 blockade and epigenetic reprogramming.

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Construction of MDR1 vectors for gene therapy

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