Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal dendritic cells

R E Petty1, D W Hunt

  • 1Department of Pediatrics, University of British Columbia, Vancouver, Canada.

Vaccine
|August 26, 1998
PubMed
Summary
This summary is machine-generated.

Dendritic cells from human cord blood show limited T cell proliferation compared to adult dendritic cells. This reduced function may contribute to weaker neonatal immune responses, but can be overcome by increasing mitogen or cell concentration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Method for Producing Perfect Joints in Gum-Section Plates.

The Dental register·2021
Same author

Pheromone production by axenically rearedDendroctonus ponderosae andIps paraconfusus (Coleoptera: Scolytidae).

Journal of chemical ecology·2013
Same author

Sex-specific production of ipsdienol and myrcenol byDendroctonus ponderosae (Coleoptera: Scolytidae) exposed to myrcene vapors.

Journal of chemical ecology·2013
Same author

Partial inhibition of pheromone production inDendroctonus ponderosae (Coleoptera: Scolytidae) by polysubstrate monooxygenase inhibitors.

Journal of chemical ecology·2013
Same author

Response of mountain pine beetle,Dendroctonus ponderosae Hopkins, and pine engraver,Ips pint (SAY), to ipsdienol in southwestern British Columbia.

Journal of chemical ecology·2013
Same author

Terpene alcohol pheromone production byDendroctonus ponderosae andIps paraconfusus (Coleoptera: Scolytidae) in the absence of readily culturable microorganisms.

Journal of chemical ecology·2013
Same journal

Immunogenicity and safety of a SARS-CoV-2 recombinant vaccine S-268024 booster vaccination versus NVX-CoV2373: Interim results from a phase 3, multicenter, randomized, observer-blind, active-controlled study.

Vaccine·2026
Same journal

Safety and immunogenicity of a reduced, homologous booster dose of the BNT162b2 mRNA COVID-19 vaccine: a single blind, randomized, non-inferiority follow-up trial.

Vaccine·2026
Same journal

Vaccination policies for healthcare personnel in Europe, 2026.

Vaccine·2026
Same journal

A historical overview of the anti-vaccine movement and its public health implications.

Vaccine·2026
Same journal

Vaccine strategies and development before and during the 1968 H3N2 influenza pandemic.

Vaccine·2026
Same journal

Influence of correlated vaccination behaviors on estimates of COVID-19 vaccine effectiveness in older adults - VISION network, October 2023 - March 2024.

Vaccine·2026
See all related articles

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are crucial antigen-presenting cells that initiate immune responses.
  • The function of neonatal immune cells, including T cells and DCs, differs from adult counterparts.

Purpose of the Study:

  • To compare the capacity of cord blood dendritic cells (CBDCs) versus adult peripheral blood dendritic cells (APBDCs) in supporting T cell proliferation.
  • To investigate the role of DC function in neonatal immune responses.

Main Methods:

  • Mixed leukocyte reaction assays were performed using human cord blood and adult peripheral blood T cells and dendritic cells.
  • T cell proliferation was measured in response to mitogens like phytohemagglutinin (PHA) and concanavalin A (ConA).

Main Results:

Related Experiment Videos

  • CBDCs demonstrated a limited ability to induce proliferation in both cord blood and adult T cells compared to APBDCs.
  • APBDCs supported equivalent mitogen-induced T cell responses in both cord blood and adult T cells.
  • The reduced function of CBDCs could be compensated by increasing mitogen concentration or DC numbers.

Conclusions:

  • Cord blood dendritic cells exhibit reduced stimulatory capacity compared to adult dendritic cells.
  • The functional deficiency of CBDCs may partially explain the attenuated primary immune responses observed in neonates.
  • Optimizing culture conditions, such as increasing mitogen or DC concentration, can enhance CBDC-mediated T cell responses.