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Early immunization with conjugate vaccines

J Eskola1, H Käyhty

  • 1National Public Health Institute, Helsinki, Finland. j.eskola@ic.ac.uk

Vaccine
|August 26, 1998
PubMed
Summary

Newborns can be safely vaccinated with conjugate vaccines, showing mild side effects. Early vaccination with Haemophilus influenzae type b (Hib) conjugates induces immune memory, potentially protecting infants from invasive Hib infections.

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Area of Science:

  • Pediatric immunology
  • Vaccinology
  • Infectious disease prevention

Background:

  • Conjugate vaccines are evaluated for safety and immune response in neonates and infants.
  • Previous studies focused on later infant vaccination schedules.

Purpose of the Study:

  • To assess the safety and immunologic behavior of conjugate vaccines in the neonatal period and early infancy.
  • To determine the antibody concentrations and immune memory induction following early-life conjugate vaccine administration.

Main Methods:

  • Administration of conjugate vaccines during the neonatal period and early infancy.
  • Monitoring of adverse events.
  • Measurement of anticapsular antibody concentrations and assessment of immune memory.

Main Results:

  • Adverse events were mild and self-resolving in neonates and premature infants.
  • Initial antibody concentrations after the first dose of Hib conjugates were low but indicated active antibody production.
  • Antibody concentrations after the primary series approached levels seen in routine vaccination programs, with evidence of early immune memory induction.

Conclusions:

  • Conjugate vaccines are safe and well-tolerated in neonates and infants.
  • Early infant vaccination with Hib conjugates induces protective antibody levels and immunological memory.
  • This suggests that protection against invasive Hib infections can be achieved early in life.

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