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Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System
Published on: January 31, 2018
Inactivated whole-cell bacterial vaccines: current status and novel strategies
J L Pace1, H A Rossi, V M Esposito
1Antex Biologics Inc., Gaithersburg, MD 20879, USA.
Vaccine
|August 26, 1998
Summary
Inactivated whole-cell vaccines offer economical disease prevention but face challenges with administration and immunity duration. Recent advancements in antigenicity and oral immunization promise enhanced efficacy for vaccines against bacteria like Vibrio cholerae and Campylobacter jejuni.
Area of Science:
- Microbiology
- Immunology
- Vaccinology
Background:
- Inactivated bacterial whole-cell vaccines are widely studied for infectious disease prophylaxis.
- Parenteral administration can cause adverse reactions, while oral administration often requires high doses and provides short-term immunity.
Purpose of the Study:
- To review recent advancements in inactivated whole-cell vaccines.
- To highlight strategies for improving vaccine antigenicity and oral immunization efficacy.
Main Methods:
- Literature review of studies on inactivated whole-cell vaccines.
- Analysis of new approaches for enhancing antigenicity and immune responses.
Main Results:
- New methods are improving the antigenicity of inactivated whole-cell vaccines.
- Enhanced immune responses are being achieved through oral immunization strategies.
Conclusions:
- Advancements offer significant hope for improving the efficacy of inactivated whole-cell vaccines.
- Promising whole-cell vaccines are being developed for Vibrio cholerae, enterotoxigenic Escherichia coli, and Campylobacter jejuni.
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