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Relationship between left ventricular hypertrophy and renal and retinal damage in untreated patients with essential
Insights
Left ventricular hypertrophy (LVH) is linked to kidney and eye damage in hypertension. Proteinuria, a marker of kidney damage, is associated with increased left ventricular mass in these patients.
Area of Science:
- Cardiology
- Nephrology
- Ophthalmology
Background:
- Essential hypertension is a significant risk factor for cardiovascular and end-organ damage.
- Left ventricular hypertrophy (LVH) is a common complication of hypertension.
- Renal and retinal damage are recognized indicators of hypertensive end-organ damage.
Purpose of the Study:
- To investigate the association between left ventricular hypertrophy (LVH) and renal and retinal damage in untreated essential hypertension patients.
- To determine if proteinuria and retinal vascular changes correlate with LVH.
Main Methods:
- Echocardiography was used to diagnose and quantify left ventricular mass for LVH.
- Proteinuria and retinal vascular changes were assessed as indicators of renal and retinal damage.
- A cohort of 174 untreated patients with essential hypertension was studied.
Main Results:
- 64% of patients (111 out of 174) exhibited LVH.
- Higher incidences of proteinuria and advanced retinal vascular changes were observed in patients with LVH compared to those without.
- Multiple regression analysis revealed a significant positive correlation between left ventricular mass and proteinuria, also considering diastolic blood pressure, sex, age, and BMI.
Conclusions:
- Proteinuria is significantly related to elevated left ventricular mass in patients with essential hypertension.
- LVH may be associated with increased risk of renal damage, indicated by proteinuria.
- These findings highlight the interconnectedness of cardiac and renal health in hypertensive individuals.
Abstract:
We examined the relationship between left ventricular hypertrophy (LVH) and renal and retinal damage in 174 untreated patients with essential hypertension. As an index of renal and retinal damage, we examined proteinuria and retinal vascular change. LVH was diagnosed according to left ventricular mass obtained from echocardiography. Of the hypertensive patients, 111 patients (64%) had LVH. The incidences of proteinuria and advanced retinal vascular change were higher in patients with LVH than in those without LVH. In a multiple regression model, there was a significant positive correlation between left ventricular mass and proteinuria, as well as diastolic blood pressure, sex, age and body mass index. In conclusion, proteinuria is related to elevated left ventricular mass in patients with essential hypertension.