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Strongyloidiasis associated with nephrotic syndrome

S Mori1, T Konishi, K Matsuoka

  • 1Department of Internal Medicine, Mie Prefectural General Medical Center, Yokkaichi.

Internal Medicine (Tokyo, Japan)
|August 26, 1998
PubMed
Summary

A nephrotic syndrome patient with eosinophilia experienced severe gastrointestinal issues and malabsorption due to strongyloidiasis, triggered by steroid therapy. Prompt diagnosis and treatment with thiabendazole led to recovery, highlighting the need to screen for strongyloidiasis before steroid use in endemic areas.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Nephrotic syndrome is a kidney disorder characterized by protein in the urine.
  • Eosinophilia, elevated eosinophils, can indicate parasitic infections or allergic reactions.
  • Strongyloidiasis is a parasitic infection caused by Strongyloides stercoralis.

Observation:

  • A patient with nephrotic syndrome and eosinophilia presented with ileus, epigastralgia, and malabsorption.
  • Symptoms became symptomatic after initiating steroid therapy.
  • Percutaneous renal biopsy confirmed minimal change nephrotic syndrome.

Findings:

  • The patient's symptoms were attributed to strongyloidiasis, which was exacerbated by corticosteroid treatment.
  • Treatment with thiabendazole resulted in complete recovery.

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  • Minimal change nephrotic syndrome in this case may be linked to severe Strongyloides stercoralis infection.

    • Implications:

    • This case underscores the critical importance of ruling out strongyloidiasis before corticosteroid therapy.
    • Patients from eosinophilia-endemic areas are at higher risk and require proactive screening.
    • Early diagnosis and treatment of strongyloidiasis can prevent severe complications in immunocompromised or steroid-treated individuals.