Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemostasis in schistosomiasis mansoni

D R Borges, M P Vilela, C C Guerra

    G.E.N
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Schistosomiasis mansoni patients with hepato-splenic form exhibit chronic consumptive coagulopathy. This condition improved with heparin or splenectomy, highlighting splenomegaly

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II.

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2018
    Same author

    Reticulated platelets and thrombopoietin in schistosomiasis patients.

    International journal of laboratory hematology·2009
    Same author

    The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone.

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2007
    Same author

    Gamma-glutamyltransferase decreases in patients with the chronic form of schistosomiasis mansoni treated with ursodeoxycholic acid.

    Journal of clinical pathology·2005
    Same author

    Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors.

    Journal of gastroenterology and hepatology·2001
    Same author

    [Biliary microcrystals in idiopathic acute pancreatitis: clue for occult underlying biliary etiology].

    Arquivos de gastroenterologia·2001
    Same journal

    [Hemochromatosis: frequent but few times diagnosed].

    G.E.N·1995
    Same journal

    [Early gastric cancer in the remnant stomach. Case report].

    G.E.N·1995
    Same journal

    [Gastrointestinal stromal sarcoma. Report of a case and review of the literature].

    G.E.N·1995
    Same journal

    [Primary intestinal lymphangiectasia in children. Report of 3 cases].

    G.E.N·1995
    Same journal

    [Von Recklinghausen disease and hepatic neurofibromatosis].

    G.E.N·1995
    Same journal

    [Effectiveness and innocuousness of the association of calcium dobesilate, dexamethasone acetate and lidocaine versus prednisolone capronate with dibucaine clorohydrate in the treatment of hemorrhoids-].

    G.E.N·1995
    See all related articles

    Area of Science:

    • Medical Research
    • Parasitology
    • Hematology

    Background:

    • Schistosomiasis mansoni is a parasitic disease affecting the hepato-intestinal and hepato-splenic systems.
    • Altered hemostasis and coagulation are potential complications in schistosomiasis patients.
    • The role of hepatocytic function and splenomegaly in coagulation disorders requires further investigation.

    Purpose of the Study:

    • To investigate hemostasis alterations in patients with hepato-intestinal versus hepato-splenic Schistosomiasis mansoni.
    • To explore the relationship between coagulation factors, hepatocytic function, and the disease forms.
    • To assess the impact of hycanthone treatment and splenectomy on coagulation parameters.

    Main Methods:

    • Comparative study of hemostasis in 18 hepato-intestinal and 23 hepato-splenic Schistosomiasis mansoni patients.

    Related Experiment Videos

  • Analysis of plasmatic coagulation factors and hepatocytic function tests.
  • Repeated explorations in 6 patients post-hycanthone administration; assessment of heparin and splenectomy effects.

    • Main Results:

    • Patients with hepato-splenic Schistosomiasis mansoni presented with chronic consumptive coagulopathy.
    • Coagulopathy resolved following heparin treatment or splenectomy.
    • Hepatocytic function tests showed correlations with coagulation factor alterations.

    Conclusions:

    • Splenomegaly is a significant factor in the development of chronic consumptive coagulopathy in Schistosomiasis mansoni.
    • Heparin and splenectomy are effective in managing coagulopathy associated with the hepato-splenic form.
    • Splenectomy may be indicated for patients with portal hypertension due to Schistosomiasis mansoni and associated coagulopathy.