Related Experiment Video
Updated: Aug 1, 2026
11:27
Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
Published on: April 29, 2014
Metastatic cervical carcinoma mimicking kidney abscess
A Takahashi1, H Adachi, A Iwasawa
1Department of Urology, Sapporo Medical University School of Medicine, Japan.
Summary
Metastatic cervical cancer can present as a kidney tumor. Human papillomavirus 16 confirmed the metastasis, explaining the patient's symptoms and fever.
Area of Science:
- Oncology
- Pathology
- Infectious Disease
Background:
- Cervical carcinoma is a common cancer in women.
- Metastasis of cervical cancer typically occurs to regional lymph nodes, lungs, liver, and bone.
- Renal metastasis from cervical carcinoma is rare.
Observation:
- A 26-year-old female with a history of cervical carcinoma presented with fever and flank pain.
- Initial diagnosis suggested a renal abscess based on symptoms and imaging.
- Pathological examination revealed squamous cell carcinoma in the kidney, matching the cervical tumor type.
Findings:
- Human papillomavirus 16 (HPV16) DNA was detected in both the renal and cervical tumors.
- This confirmed the renal tumor as a metastasis from the primary cervical carcinoma.
- Interleukin-6 (IL-6) was discussed as a potential cause for the patient's fever.
Implications:
- This case highlights the importance of considering rare metastatic patterns in cancer patients.
- HPV16 serves as a valuable marker for confirming metastasis origin.
- Understanding the role of cytokines like IL-6 may offer insights into cancer-related symptoms.
Related Concept Videos
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
01:26Nursing Assessment of the Genitourinary System II: Inspection and Palpation
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...