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Peripheral blood stem cell mobilization with granulocyte colony-stimulating factor and a harvesting procedure in
Y Kawano1, Y Takaue, T Watanabe
1Department of Pediatrics, The University of Tokushima, Japan.
Insights
Pediatric donors can safely receive granulocyte colony-stimulating factor (G-CSF) for peripheral blood stem cell (PBSC) mobilization. Higher G-CSF doses may be beneficial for small children donating to adult patients, considering side-effects and G-CSF kinetics.
Area of Science:
- Hematology
- Pediatric Medicine
- Transplantation
Background:
- The safety of granulocyte colony-stimulating factor (G-CSF) administration in healthy pediatric donors for peripheral blood stem cell (PBSC) mobilization is not well-established.
- PBSC collection is a critical component of hematopoietic stem cell transplantation.
Purpose of the Study:
- To evaluate the efficacy and safety of PBSC mobilization and harvesting in pediatric donors.
- To compare PBSC mobilization and harvesting in pediatric donors versus adult donors.
Main Methods:
- A comparative study analyzing PBSC mobilization and harvesting protocols.
- Evaluation of G-CSF kinetics and side-effect frequency in pediatric donors.
Main Results:
- PBSC mobilization and harvesting protocols are safe and effective in normal pediatric donors.
- Pediatric donors experienced a lower frequency of side-effects and lower white blood cell (WBC) counts compared to adult donors.
Conclusions:
- The established PBSC mobilization and harvesting protocol is safe and effective for pediatric donors.
- Higher doses of G-CSF may be recommended for pediatric donors, especially small children donating to adult patients, to optimize PBSC yield and manage G-CSF kinetics.
Abstract:
The safety of injecting healthy donors with granulocyte colony-stimulating factor (G-CSF) has not been established. To evaluate PBSC mobilization and harvesting efficacy in the pediatric population, we compared it with those in adult donors. In this study, we conclude that PBSC mobilization and harvesting protocol in normal pediatric donors can be performed safely and effectively. Considering the lower frequency of side-effects and WBC counts, and G-CSF kinetics, higher dose of G-CSF would be recommended when small children become donors for adult patients.