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Beta interferon is produced by Chlamydia trachomatis-infected fibroblast-like synoviocytes and inhibits gamma
1Institute of Medical Microbiology, Friedrich Schiller University of Jena, D-07743 Jena, Germany. Roedel@BACH.med.uni-jena.de
Infection and Immunity
|August 26, 1998
Abstract:
Infection of fibroblast-like synovial cells with Chlamydia trachomatis (serotype D strain IC Cal 8) in culture induced the secretion of beta interferon (IFN-beta). Chlamydial infection inhibited IFN-gamma-induced expression of HLA-DR antigen in the cells. Addition of IFN-beta antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-beta.