Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Genetic considerations in chronic simple glaucoma]

D P Popa1, C C Albu, L E Popescu

  • 1Clinica Oftalmologică, Spitalul Universitar Bucureşti.

Oftalmologia (Bucharest, Romania : 1990)
|August 26, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxidative damage following cerebral ischemia depends on reperfusion - a biochemical study in rat.

Journal of cellular and molecular medicine·2002
Same author

The quantification of intrahemispheric EEG asymmetry in rat.

Romanian journal of physiology : physiological sciences·2000
Same author

EEG differences between the opioid and adrenergic psyhoneuroendocrine rat types.

Romanian journal of physiology : physiological sciences·2000
Same author

[Phacotopic glaucoma].

Oftalmologia (Bucharest, Romania : 1990)·1998
Same author

[The efficacy of Cairns trabeculectomy in open-angle glaucoma].

Oftalmologia (Bucharest, Romania : 1990)·1998
Same author

[An update on the chemotherapy of malignant ocular tumors].

Oftalmologia (Bucharest, Romania : 1990)·1995
Same journal

[Macular serpiginous choroiditis complicated by macular hole].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Therapeutic approach in persistent diabetic macular edema].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Preliminary results of treatment with aflibercept].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

MANAGEMENT OF DIABETIC RETINOPATHY, PREVALENCE AND CLINICAL CLASSIFICATION.

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Changes in intraocular pressure depending on posture].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Treatment for penetrating wound caused by metallic intraocular foreign body].

Oftalmologia (Bucharest, Romania : 1990)·2015
See all related articles

Primary open-angle glaucoma shows hereditary transmission in over 43% of cases. Understanding genetic patterns, like autosomal dominant or recessive, is crucial for accurate recurrence risk assessment and effective disease prevention.

Area of Science:

  • Ophthalmology
  • Genetics
  • Medical Science

Context:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Understanding the genetic basis of POAG is essential for early diagnosis and intervention.
  • Previous studies have indicated a familial component, but detailed genetic transmission patterns require further elucidation.

Purpose:

  • To investigate the hereditary transmission patterns of primary open-angle glaucoma in a Romanian patient cohort.
  • To determine the modes of genetic transmission (autosomal dominant, autosomal recessive) within affected families.
  • To calculate the recurrence risk for offspring based on identified genetic patterns.

Summary:

  • A study of primary open-angle glaucoma patients revealed hereditary transmission in 43.11% of cases.

Related Experiment Videos

  • Genetic analysis identified autosomal dominant transmission in 58.33% and autosomal recessive in 38.88% of families.
  • Recurrence risks were calculated as 50% for autosomal dominant and 0.5% for autosomal recessive inheritance.

    • Impact:

    • Highlights the significant role of genetics in POAG etiology.
    • Emphasizes the necessity of comprehensive family investigations and genealogical analysis for POAG patients.
    • Provides crucial data for genetic counseling and the development of targeted prophylactic strategies to reduce disease recurrence.