Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Allylamine type xanthone antimycotics

I Salmoiraghi1, M Rossi, P Valenti

  • 1Institute of Pharmaceutical Chemistry, University of Milan, Italy.

Archiv Der Pharmazie
|August 26, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multitryptophan-fluorescence-emission decay of beta-glycosidase from the extremely thermophilic archaeon Sulfolobus solfataricus.

European journal of biochemistry·1997
Same author

Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight.

Endocrinology·1997
Same author

One-year follow-up after laparoscopic Heller-Dor operation for esophageal achalasia.

Surgical endoscopy·1997
Same author

Perturbation of conformational dynamics, enzymatic activity, and thermostability of beta-glycosidase from archaeon Sulfolobus solfataricus by pH and sodium dodecyl sulfate detergent.

Proteins·1997
Same author

Type I hereditary angio-oedema. Variability of clinical presentation and course within two large kindreds.

Journal of internal medicine·1997
Same author

Combined liver and islet transplantation: about one case.

Transplant international : official journal of the European Society for Organ Transplantation·1997
Same journal

Spinal 5-HT<sub>1A</sub> Receptor-Related and Microglial Mechanisms Associated With Intrathecal Cannabidiol-Induced Antinociception in Neuropathic Pain.

Archiv der Pharmazie·2026
Same journal

The Potential Targets of Novel Triazine Derivatives on Mechanisms of Apoptosis, Regulation of the Cell Cycle, and Endoplasmic Reticulum Stress Pathways in Human Lung Cancer.

Archiv der Pharmazie·2026
Same journal

Chaperone-Mediated Autophagy-Directed Degradation of PI3K in Tumor Cells: Development of Multifunctional Peptide-Drug Conjugates With Enhanced Penetration and Selectivity.

Archiv der Pharmazie·2026
Same journal

Efficient Radiosynthesis of <sup>99m</sup>Tc-Amygdalin for Tumor Imaging Using a <sup>99</sup>Mo/<sup>99m</sup>Tc Generator Based on Alumina Doped With Terbium Oxide.

Archiv der Pharmazie·2026
Same journal

Structure-Based Discovery of N-Aryl-N'-Heteroaryl Ureas as Disruptors of the Oncogenic MTDH-SND1 Protein-Protein Interaction: In Silico Insights and Biochemical Validation.

Archiv der Pharmazie·2026
Same journal

Dual Anti-Cancer and Anti-Inflammatory Activity of Some New Benzofuran-Thiazole Hybrids With Promising COX-2 Inhibitory Potency: Cell-Cycle Arrest, Apoptosis, and Safety Study.

Archiv der Pharmazie·2026
See all related articles

New xanthone derivatives were synthesized and tested for antifungal properties. Butenafine-based xanthone analogs demonstrated significant activity against Cryptococcus neoformans, with regioisomer 4d showing particular potency.

Area of Science:

  • Medicinal Chemistry
  • Mycology
  • Organic Synthesis

Background:

  • Antifungal drug discovery is crucial for treating infections caused by molds and yeasts.
  • Naftifine and butenafine are established allylamine antifungal agents.
  • Xanthone scaffolds are explored for novel therapeutic applications.

Purpose of the Study:

  • To synthesize novel xanthone derivatives incorporating the side chains of naftifine and butenafine.
  • To evaluate the in vitro antifungal activity of these novel compounds.
  • To identify potent antifungal agents, particularly against challenging fungal pathogens.

Main Methods:

  • Synthesis of xanthone derivatives with basic side chains at nuclear positions 1, 2, 3, and 4.
  • In vitro antifungal screening against various mold and yeast strains.

Related Experiment Videos

  • Determination of minimum inhibitory concentrations (MICs) for active compounds.

    • Main Results:

    • Several xanthone derivatives were successfully synthesized.
    • Butenafine-based xanthone analogs exhibited significant antifungal activity.
    • Regioisomer 4d, a butenafine xanthone analog, showed potent activity against Cryptococcus neoformans with an MIC of 1.5 µg/ml.

    Conclusions:

    • Butenafine xanthone analogs represent a promising class of antifungal compounds.
    • Regioisomer 4d is a highly effective inhibitor of Cryptococcus neoformans growth.
    • Further investigation into these derivatives may lead to new antifungal therapies.