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Glutamic acid and Alzheimer's disease
C Arias1, F Becerra-García, R Tapia
1Departamento de Neurociencias, Universidad Nacional Autónoma de México, México D.F.
Neurobiology (Budapest, Hungary)
|August 26, 1998
Abstract:
Neurotoxicity mediated by glutamate is thought to play a role in neurological disorders such a stroke, ischemia and slowly progressing neurodegenerative diseases. However, the contribution of excitotoxicity in neuronal death that occurs in Alzheimer's disease is still an open question. This paper briefly reviews the main lines of evidence supporting a participation of excess glutamatergic neurotransmission in the neurodegeneration of selective groups of neurons in this disease.