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Familial schizophrenia with pericentric inversion of chromosome 9: a case report
1Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan. klee@med.teikyo-u.ac.jp
Schizophrenia Research
|August 26, 1998
Abstract:
We report a case with schizophrenia who had a pericentric inversion of chromosome 9 (inv. 9) and whose mother has the same illness and karyotype. Although inv. 9 has been considered to be a common chromosomal rearrangement without specific phenotype, recent evidence has shown that there are several different forms of inv. 9 with differential breakpoints. This indicates that phenotypes of inv. 9 may vary depending on the location of breakpoints. Thus our cases may be valuable material to localize breakpoints on chromosome 9, which may lead to cloning of a susceptibility gene for schizophrenia.