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Updated: Jul 26, 2026
Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
Published on: January 21, 2017
Very late pain-related activity identified with topographically mapped frequency domain analysis of evoked potentials
1Department of Anesthesia, University of California, San Francisco 94143-0648, USA. dbecker@itsa.ucsf.edu
Objective:
To identify low-frequency activity in the pain-evoked potential at very late latencies, consistent with C-fiber transmission velocities.
Methods:
Brief (1 ms) painful (intracutaneous) and two levels of non-painful (mild and strong) electrical pulses were applied to the index and middle fingers of the left hand. Evoked potentials (EPs) were recorded from 30 electrodes covering the entire scalp. Data from the 3 stimulus conditions (approximately 60 trials per condition per subject) were compared using the frequency domain technique of complex demodulation applied to single trial data. Subjects were 14 normal right-handed male human volunteers, aged 19-36 years.
Results:
Using descriptive probability mapping, pain versus strong non-pain differences were found in grand average data as well as in 8 of 14 subjects, consisting of greater low-frequency power at latencies from 700 to 1100 ms at electrodes near the contralateral central sulcus and at the vertex.
Conclusions:
There are topographically focal, pain versus non-pain differences in the 700-1100 ms latency range that can be seen using frequency-domain analytic techniques. These differences were not seen with traditional time domain analyses. They may be due to a C-fiber-related mechanism or to very late activity triggered by faster fibers.
