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Related Experiment Videos

Gammadelta T-cell precursor-derived CD4- CD8- alphabeta T cells retain gammadelta cell function

M Fritsch1, F Ivars

  • 1Gastrointestinal Pharmacology, Astra Hässle AB, Mölndal, Sweden.

Scandinavian Journal of Immunology
|August 26, 1998
PubMed
Summary

T cells expressing different T cell receptors (TcR) show similar functions, suggesting effector functions are determined early in T cell development, independent of TcR type.

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Area of Science:

  • Immunology
  • T cell biology
  • Cellular immunology

Background:

  • Some double-negative (DN) alpha-beta+ T cells in transgenic mice originate from gamma-delta T cells.
  • Previous studies identified these cells using phenotypic data and T cell receptor (TcR) gene rearrangements.

Purpose of the Study:

  • To investigate the functional impact of alpha-beta TcR expression on mature gamma-delta precursor-derived DN alpha-beta+ T cells.
  • To determine if TcR isotype influences T cell effector functions and lineage commitment.

Main Methods:

  • Analysis of T cells from TcR alpha-chain transgenic mice.
  • Phenotypic characterization of double-negative (DN) alpha-beta+ T cells.
  • Assessment of T cell receptor (TcR) gene rearrangements.
  • Evaluation of proliferative capacity and cytokine production.

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  • Analysis of CD8alpha upregulation and B cell proliferation induction.

    • Main Results:

    • DN alpha-beta+ T cells derived from gamma-delta precursors exhibit proliferative capacity and cytokine profiles similar to gamma-delta T cells.
    • Both transgenic DN alpha-beta+ T cells and DN gamma-delta+ T cells upregulate CD8alpha upon activation.
    • Unlike CD4+ alpha-beta T cells, these DN T cells cannot induce naive B cell proliferation.

    Conclusions:

    • T cell effector functions are likely determined independently of the TcR isotype, possibly during early differentiation stages.
    • These findings challenge current models of T-cell lineage commitment by suggesting a differentiation-based rather than TcR-dependent functional programming.
    • The study highlights the plasticity of T cell development and the factors influencing mature T cell effector functions.