Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Otoconial agenesis in tilted mutant mice

D M Ornitz1, B A Bohne, I Thalmann

  • 1Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA. dornitz@pharmdec.wustl.edu

Hearing Research
|August 26, 1998
PubMed
Summary

The tilted mouse mutant lacks otoconia, essential for sensing gravity, leading to balance dysfunction. This specific defect offers a unique model for studying vestibular development and pathophysiology without other organ system abnormalities.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TAVI plus PCI versus SAVR plus CABG: Long-term outcome of a multicentre-registry.

Clinical research in cardiology : official journal of the German Cardiac Society·2025
Same author

Eccentric hypertrophy impairs outcome after TAVR.

Clinical research in cardiology : official journal of the German Cardiac Society·2024
Same author

[Injury of the profunda femoris artery with bleeding requiring transfusion due to secondary dislocation of the lesser trochanter after osteosynthesis of an intertrochanteric femoral fracture].

Der Unfallchirurg·2020
Same author

Effect of gloved hand disinfection on hand hygiene before infection-prone procedures on a stem cell ward.

The Journal of hospital infection·2019
Same author

Survival after neoadjuvant chemotherapy with or without bevacizumab or everolimus for HER2-negative primary breast cancer (GBG 44-GeparQuinto)†.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Optical symbolic substitution using diffraction gratings.

Applied optics·2010

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Sensory Systems Biology

Background:

  • The sense of balance relies on vestibular organs, conserved throughout vertebrate evolution.
  • Understanding vestibular development and pathophysiology is crucial for treating balance disorders.

Purpose of the Study:

  • To analyze the spontaneous mouse mutant, tilted (tlt), for vestibular dysfunction.
  • To investigate the genetic and physiological basis of the tilted mouse's gravity receptor defect.

Main Methods:

  • Phenotypic analysis of the 'tilted' (tlt) mouse mutant.
  • Comparative analysis with other vestibular mouse mutants (head tilt, pallid, mocha).
  • Histological examination of vestibular organs and sensory epithelium.

Related Experiment Videos

Main Results:

  • The 'tilted' mouse specifically lacks otoconia, crucial for sensing gravity.
  • This otoconia deficiency leads to a complete loss of gravity-sensing ability.
  • Unlike other mutants, 'tilted' shows no sensory epithelium degeneration or other organ system defects.

Conclusions:

  • The 'tilted' mouse provides a highly penetrant, specific model for otoconia absence.
  • This mutant is valuable for studying vestibular development and the mechanisms underlying balance disorders.
  • The absence of secondary defects makes 'tilted' ideal for focused research on otoconia formation and function.