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Nuclear hormone receptors and adipogenesis
J M Gimble1, C E Robinson, S L Clarke
1Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
Critical Reviews in Eukaryotic Gene Expression
|August 26, 1998
Summary
Adipocytes are key for studying nuclear hormone receptor regulation, influencing lipid metabolism and cell commitment. This review covers models for understanding these complex interactions.
Area of Science:
- Molecular Biology
- Cell Biology
- Endocrinology
Background:
- Adipocytes are crucial for lipid and cholesterol metabolism.
- Nuclear hormone receptors regulate adipocyte function and commitment.
- Coactivators and corepressors add complexity to transcriptional regulation.
Purpose of the Study:
- To review models for studying nuclear hormone receptor transcriptional regulation in adipocytes.
- To discuss current controversies and future research directions in this field.
Main Methods:
- Review of in vitro models.
- Review of in vivo models.
Main Results:
- Adipocytes produce ligands for nuclear hormone receptors.
- Nuclear hormone receptors impact adipocyte differentiation.
- Coactivators/corepressors modulate receptor activity.
Conclusions:
- Adipocyte models are essential for understanding nuclear hormone receptor function.
- Further research is needed to clarify controversies and explore new experimental avenues.