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Pseudomyxoma peritonei. A report of three cases and a review of published reports
1Department of Surgery, Kurume University School of Medicine, Japan.
Abstract:
Pseudomyxoma peritonei is a disease characterized by the progressive accumulation of mucinous ascites within the abdomen and pelvis. Metastatic disease outside the peritoneal cavity is unusual. Gastrointestinal function is lost from external compression of stomach, small bowel, and large bowel. We present three cases of pseudomyxoma peritonei which were treated by different therapeutic methods. Case 1 was a 61-year-old man who underwent treatment by appendectomy with administration of Cisplatin and Doxorubicin hydrochloride into the intraperitoneal cavity. Case 2 was a 64-year-old woman who underwent bilateral oophorectomy with administration of Cisplatin and ADM into the intraperitoneal cavity. About 4 years after the first operation, she died of peritonitis due to small and large bowel perforations underlying recurrent tumors. Case 3 was a 79-year-old woman who underwent surgery to evacuate about 4000 ml of mucinous ascites, and received intraperitoneal administration of 5-Fluorouracil (500 mg/day) for 5 days without severe complications.
Insights
Pseudomyxoma peritonei involves mucinous ascites accumulation. This study explores varied treatments for this rare condition, highlighting different therapeutic approaches and outcomes in three patient cases.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Pseudomyxoma peritonei is a rare condition characterized by mucinous ascites accumulation in the abdomen and pelvis.
- It often leads to gastrointestinal dysfunction due to external compression, with extrperitoneal spread being uncommon.
Observation:
- Three cases of pseudomyxoma peritonei treated with different methods were analyzed.
- Treatments included appendectomy with intraperitoneal chemotherapy (Cisplatin and Doxorubicin hydrochloride), bilateral oophorectomy with intraperitoneal chemotherapy (Cisplatin and ADM), and surgical debulking with intraperitoneal 5-Fluorouracil.
Findings:
- Case 1: Appendectomy with intraperitoneal Cisplatin and Doxorubicin hydrochloride.
- Case 2: Bilateral oophorectomy with intraperitoneal Cisplatin and ADM resulted in peritonitis and death after 4 years due to recurrent tumors.
- Case 3: Surgical debulking and 5-day intraperitoneal 5-Fluorouracil administration showed no severe complications.
Implications:
- Different therapeutic strategies yield varied outcomes in pseudomyxoma peritonei.
- Intraperitoneal chemotherapy and surgical debulking are potential treatment modalities.
- Further research is needed to optimize treatment protocols for pseudomyxoma peritonei.