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Related Experiment Videos

[Acardius (TRAP-sequence) (Twin Reversed Arterial Perfusion)]

P Patkós1, E Hruby, T Marton

  • 1I. sz. Szülészeti és Nógyógyászati Klinika, Semmelweis Orvostudományi Egyetem, Budapest.

Orvosi Hetilap
|August 26, 1998
PubMed
Summary

Two cases of acardius, a rare twin pregnancy complication, were observed, revealing an incidence significantly higher than previously reported. This highlights the need for advanced prenatal diagnosis and intervention strategies for acardiac twins.

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Area of Science:

  • Perinatology
  • Maternal-Fetal Medicine
  • Reproductive Genetics

Background:

  • Acardius is a rare congenital anomaly in monozygotic twin pregnancies.
  • It involves severe malformations, typically with one twin lacking a heart and other structures.
  • The condition poses significant risks to both fetuses and requires specialized management.

Observation:

  • Two cases of acardius were identified over a seven-year period (1990-1997) at a single institution.
  • This observation occurred among nearly 20,000 deliveries.
  • The observed incidence was notably higher than established literature values.

Findings:

  • The study reports an incidence of acardius more than three times higher than generally cited in medical literature.
  • Detailed case presentations are provided.

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  • Contemporary prenatal diagnostic capabilities for this condition are discussed.

    • Implications:

    • The findings suggest a potentially higher prevalence of acardius than previously understood.
    • Enhanced prenatal diagnosis is crucial for timely identification and management.
    • Emerging intrauterine therapies, including laser occlusion of connecting vessels, offer promising treatment avenues for acardiac twins.