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Pertussis infection in adults

¹Department of Emergency Medicine, Vanderbilt University, Nashville, Tenn. 37212, USA.

Southern Medical Journal

|August 26, 1998

Summary

Pertussis is common in adults due to waning immunity, making them a reservoir for the disease. Booster immunization with acellular vaccines could eliminate pertussis in all age groups.

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Area of Science:

Infectious Diseases
Immunology
Public Health

Background:

Pertussis (whooping cough) is a vaccine-preventable illness that frequently affects adults.
Adults are a significant reservoir for pertussis transmission in the United States, often unrecognized by clinicians.
Waning immunity contributes to the high prevalence of pertussis in the adult population.

Purpose of the Study:

To review the epidemiology, clinical presentation, diagnosis, and treatment of pertussis in adults.
To highlight the role of adults as a reservoir for pertussis.
To discuss the potential impact of adult booster immunization on disease elimination.

Main Methods:

A comprehensive MEDLINE search of English-language articles on pertussis in adults was performed.
Relevant findings from the literature search were synthesized into a narrative review format.

Main Results:

Pertussis commonly presents as a prolonged cough illness in adults, often following upper respiratory symptoms.
Sporadic cases and occasional outbreaks occur in diverse settings, including educational institutions and healthcare facilities.
The review covers diagnostic approaches and therapeutic strategies for adult pertussis.

Conclusions:

Waning immunity necessitates considering pertussis in adult patients presenting with prolonged cough.
Routine booster immunization for adults using acellular pertussis vaccines is proposed as a strategy to control and potentially eliminate the disease in both children and adults.

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