Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triglyceride lipases in acute hepatitis

J Sauar, J P Blomhoff, E Gjone

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |September 20, 1976
    PubMed
    Summary

    Acute hepatitis patients showed reduced lipoprotein lipase (LPL) and hepatic triglyceride lipase (H-TGL) activity. This, along with lecithin: cholesterol acyltransferase (LCAT) deficiency, contributes to high triglycerides in low-density lipoproteins (LDL).

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    C-reactive protein: a predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based study.

    Gut·2008
    Same author

    Evaluation of a novel colonoscope designed for easier passage through flexures: a randomized study.

    Endoscopy·2005
    Same author

    Polyethylene glycol versus sodium phosphate in bowel cleansing for colonoscopy: a randomized trial.

    Endoscopy·2005
    Same author

    Health-related quality of life in patients with inflammatory bowel disease five years after the initial diagnosis.

    Scandinavian journal of gastroenterology·2004
    Same author

    Capsule endoscopy in a patient with Zenker's diverticulum.

    Endoscopy·2003
    Same author

    Screening of first degree relatives of patients operated for colorectal cancer: evaluation of fecal calprotectin vs. hemoccult II.

    Digestion·2001

    Area of Science:

    • Biochemistry
    • Lipid Metabolism
    • Hepatology

    Background:

    • Investigating the roles of lipoprotein lipase (LPL) and hepatic triglyceride lipase (H-TGL) in lipid metabolism.
    • Understanding the impact of acute hepatitis on plasma lipases and lipid profiles.

    Observation:

    • Lipoprotein lipase (LPL) and hepatic triglyceride lipase (H-TGL) activities were significantly reduced in patients with acute hepatitis.
    • Patients exhibited increased triglyceride content in low-density lipoproteins (LDL), with two cases of hypertriglyceridemia.
    • Lecithin: cholesterol acyltransferase (LCAT) activity was found to be low, either absolutely or relatively, in affected patients.

    Findings:

    • Reduced activities of both LPL and H-TGL were observed during the acute phase of hepatitis.
    • LCAT deficiency, alongside lipase deficiencies, contributes to elevated LDL triglycerides in liver disease.
    • Heparin-sepharose affinity chromatography effectively separated and studied the two key triglyceride lipases.

    Implications:

    • The findings suggest a multifactorial cause for hypertriglyceridemia in acute hepatitis, involving both lipase and LCAT dysfunction.
    • This research highlights the complex interplay between liver function, lipase activity, and lipoprotein metabolism.
    • Understanding these mechanisms can inform potential therapeutic strategies for managing dyslipidemia in liver disease.

    Related Experiment Videos