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Spontaneous and chemically induced proliferative lesions in Tg.AC transgenic and p53-heterozygous mice
J F Mahler1, N D Flagler, D E Malarkey
1National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Abstract:
Recently, the use of selected genetically altered mouse models in the detection of carcinogens after short-term chemical exposures has been evaluated. Studies of several chemicals conducted by the National Toxicology Program in Tg.AC transgenic and heterozygous p53-deficient mice have been completed recently and represent a major contribution to this effort, as well as the largest accumulation to date of toxicologic pathology data in these 2 lines of mice. The purpose of this report is to describe the proliferative target organ effects observed in this set of studies, as well as to present the tumor profile in the control groups of this data set. These findings provide a comprehensive toxicologic assessment of these 2 genetically altered mouse strains, which are of emerging importance in toxicologic pathology.
Insights
Genetically altered mouse models, including Tg.AC transgenic and p53-deficient mice, are valuable tools for carcinogen detection. These studies provide extensive toxicologic pathology data, aiding in the assessment of chemical exposures.
Area of Science:
- Toxicologic Pathology
- Genetically Altered Mouse Models
- Carcinogen Detection
Background:
- Genetically altered mouse models are increasingly used for carcinogen detection.
- The National Toxicology Program (NTP) has conducted extensive studies using these models.
- Large datasets of toxicologic pathology are emerging for these strains.
Purpose of the Study:
- To evaluate genetically altered mouse models for short-term carcinogen detection.
- To describe proliferative target organ effects in Tg.AC and p53-deficient mice.
- To present the tumor profile in control groups of these mouse models.
Main Methods:
- Utilized Tg.AC transgenic mice.
- Employed heterozygous p53-deficient mice.
- Analyzed data from short-term chemical exposure studies.
Main Results:
- Observed proliferative target organ effects in the evaluated mouse models.
- Characterized tumor profiles in control groups.
- Accumulated significant toxicologic pathology data.
Conclusions:
- Tg.AC transgenic and p53-deficient mice are important models in toxicologic pathology.
- These models contribute significantly to carcinogen detection efforts.
- The findings offer a comprehensive toxicologic assessment of these mouse strains.