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A comparison of prosthetic materials used to repair abdominal wall defects
1Second Department of Surgery, Yamanashi Medical University, Yamanashi, Japan.
Insights
Vicryl mesh is the best prosthetic material for closing large abdominal wall defects in pediatric patients, as it minimizes adhesions without impacting weight gain. This finding aids in selecting optimal materials for abdominoplasty procedures.
Area of Science:
- Biomedical Engineering
- Surgical Innovation
- Pediatric Surgery
Background:
- Large abdominal wall defects necessitate prosthetic materials for effective closure.
- Abdominoplasty in pediatric patients requires careful consideration of biomaterial safety and efficacy.
Purpose of the Study:
- To determine the optimal prosthetic material for closing abdominal wall defects in pediatric surgical cases.
- To evaluate the impact of different prosthetic materials on adhesion formation and animal weight gain.
Main Methods:
- A study involving 128 Wistar KY male rats (3 weeks old) with surgically created abdominal wall defects (3 cm diameter).
- Comparison of primary closure versus closure with various prosthetic materials (Groups 1-6), with a sham operation group (Group 7).
- Assessment of adhesion scores and daily weight measurements at 3 and 9 weeks post-operation.
Main Results:
- Vicryl mesh demonstrated the lowest adhesion scores among all tested prosthetic materials.
- No significant adverse effects on weight gain were observed in rats where Vicryl mesh was used.
- Primary closure and other prosthetic materials showed varying degrees of adhesion formation.
Conclusions:
- Vicryl mesh is a highly effective biomaterial for managing large abdominal wall defects in pediatric surgical contexts.
- The use of Vicryl mesh minimizes the risk of intra-abdominal adhesions, a common surgical complication.
- This study provides evidence-based guidance for material selection in pediatric abdominoplasty and defect repair.
Abstract:
Large abdominal wall defects may require a prosthesis for closure. The aim of our study was to identify the best material for abdominoplasty in pediatric patients. One hundred twenty-eight Wistar KY strain male rats (3 weeks old) were used. All animals underwent celiotomy via a midline skin incision. They were divided into seven groups as follows: the animals in groups 1 through 6 underwent full-thickness abdominal wall excision 3 cm in diameter. The animals in group 1 underwent primary closure. In groups 2 through 6 the defect was closed with prosthetic material. In Group 7, a sham operation was performed. Daily weights were measured. The animals were killed after 3 and 9 weeks. Adhesion scores were assigned for each group. Vicryl mesh resulted in the fewest adhesions and had no effect on weight gain in the developing rats.