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Related Concept Videos

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity07:52

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

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Here we describe a rapid and direct in vivo CRISPR/Cas9 screening methodology using ultrasound-guided in utero embryonic lentiviral injections to simultaneously assess functions of several genes in the skin and oral cavity of immunocompetent...
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In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression08:54

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This protocol outlines the steps needed to generate a model system in which the transcription of an endogenous gene of interest can be conditionally controlled in live animals or cells using enhanced lac repressor and/or tet activator...
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A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer11:53

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This protocol describes the steps for cloning multiple single guide RNAs into one guide RNA concatemer vector, which is of particular use in creating multi-gene knockouts using CRISPR/Cas9 technology. The generation of double knockouts in intestinal organoids is shown as a possible application of this...
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Generation of Genetically Modified Mice through the Microinjection of Oocytes10:19

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The microinjection of mouse oocytes is commonly used for both classic transgenesis (i.e., the random integration of transgenes) and CRISPR-mediated gene targeting. This protocol reviews the latest developments in microinjection, with a particular emphasis on quality control and genotyping...
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RNA interference (RNAi) possesses many advantages over gene knockout and has been broadly used as a tool in gene functional studies. The invention of DNA vector-based RNAi technology has made long term and inducible gene knockdown possible, and also increased the feasibility of gene silencing in...
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Related Experiment Video

Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
07:52

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

Published on: November 2, 2020

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Cardiac rehabilitation

H Gohlke1, C Gohlke-Bärwolf

  • 1Rehabilitationsklinik Sinnighofen, Bad Krozingen, Germany.

European Heart Journal
|August 26, 1998
PubMed
Summary
This summary is machine-generated.

Cardiac rehabilitation programs improve patient outcomes and longevity. Patients need education on adhering to medical regimens alongside lifestyle changes for maximum benefit after a cardiac event.

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Related Experiment Videos

Last Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
07:52

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In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
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A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer
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Area of Science:

  • Cardiology
  • Preventive Medicine
  • Rehabilitation Medicine

Background:

  • Cardiac rehabilitation (CR) is a proven multifactorial intervention.
  • CR improves functional capacity, emotional well-being, return-to-work rates, and longevity.
  • CR is cost-effective and can be considered causal therapy.

Purpose of the Study:

  • To highlight the importance of integrating pharmacological treatment with non-pharmacological CR strategies.
  • To emphasize patient education on adhering to recommended medical regimens.
  • To underscore CR's role in preventing cardiac complications and disease progression.

Main Methods:

  • Review of existing meta-analyses and studies on cardiac rehabilitation.
  • Analysis of treatment adherence in studies like EuroAspire.
  • Focus on the integration of medical and non-pharmacological approaches.

Main Results:

  • Previous meta-analyses may not have fully accounted for pharmacological lipid-lowering therapies.
  • Adherence to recommended medical treatment strategies in some studies was suboptimal.
  • CR enhances the application of medical knowledge to improve cardiovascular health.

Conclusions:

  • Cardiac rehabilitation programs must educate patients on the necessity of prescribed medical treatments.
  • Combining non-pharmacological CR with appropriate medical regimens maximizes patient benefits.
  • CR is crucial for improving cardiorespiratory fitness, survival, and overall cardiological management post-cardiac event.