Related Experiment Video

Updated: Aug 10, 2026

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions
12:23

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions

Published on: October 13, 2015

Bidirectional signaling between Yersinia and its target cell

M Fällman1, C Persson, K Schesser

  • 1Department of Cell and Molecular Biology, Umeå University, Sweden.

Folia Microbiologica
|August 26, 1998
PubMed

Insights

Pathogenic Yersinia bacteria evade early host immune defenses by disrupting host cell signaling. This allows Yersinia to proliferate in lymphatic tissues, causing infection.

Area of Science:

  • Microbiology
  • Immunology
  • Bacterial Pathogenesis

Background:

  • Pathogenic Yersinia species evade host immune responses.
  • Bacterial virulence factors are crucial for Yersinia survival and proliferation.
  • Host-pathogen interactions involve complex signaling pathways.

Purpose of the Study:

  • To elucidate the signaling mechanisms employed by pathogenic Yersinia to overcome host immune defenses.
  • To understand how Yersinia virulence proteins impact host cell signaling.

Main Methods:

  • Investigating bacterial-host cell interactions during Yersinia infection.
  • Analyzing the expression and delivery of Yersinia virulence proteins (Yops).
  • Studying the effects of Yops on host cell signaling pathways.

Main Results:

  • Yersinia proliferation in lymphatic tissue is facilitated by evading early host immune responses.
  • Bacterial-host cell signaling triggers the expression and injection of Yersinia effector proteins (Yops).
  • Yops interfere with host cell signaling pathways essential for pathogen elimination.

Conclusions:

  • Pathogenic Yersinia utilizes sophisticated signaling strategies to subvert host immunity.
  • The Yops effector proteins play a critical role in disrupting host cell defense mechanisms.
  • Understanding these interactions is key to developing strategies against Yersinia infections.

More Related Videos

Unravelling the Function of a Bacterial Effector from a Non-cultivable Plant Pathogen Using a Yeast Two-hybrid Screen11:30

Unravelling the Function of a Bacterial Effector from a Non-cultivable Plant Pathogen Using a Yeast Two-hybrid Screen

Published on: January 20, 2017

Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth08:36

Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth

Published on: May 31, 2024

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
Plague01:24

Plague

Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...