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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
[Sinus aspergillosis after an endodontic treatment. Presentation of a clinical case]
A Milián Masanet1, J V Bagán Sebastián, J Riera Grimalt
1Departamento de Estomatología, Facultad de Medicina y Odontología, Hospital General Universitario, Valencia.
Abstract:
Aspergillosis is an opportunistic deep mycosis that occurs in immunocompromised patients, often in the paranasal sinuses. However, it sometimes occurs in healthy subjects, producing symptoms similar to those of a chronic sinusitis that is unresponsive to conventional treatment. A possible entry point for Aspergillus is the oroantral communication originated by perforation of the dental root cavity during root canal of a molar with penetration of material. We report the clinical case of a patient with symptoms of chronic sinusitis who was diagnosed as sinus aspergillosis after radiological and histological study. The origin may have been a third upper molar in which a root canal was performed.
Insights
Sinus aspergillosis can affect healthy individuals, mimicking chronic sinusitis unresponsive to treatment. Dental procedures, like root canals, may create an oroantral communication, serving as an entry point for Aspergillus.
Area of Science:
- Mycology
- Otolaryngology
- Dentistry
Background:
- Aspergillosis is a fungal infection typically affecting immunocompromised individuals.
- It often manifests as a deep mycosis, commonly involving the paranasal sinuses.
- However, cases in healthy subjects present challenges due to symptoms mimicking refractory chronic sinusitis.
Observation:
- A clinical case is presented involving a patient with chronic sinusitis symptoms.
- Radiological and histological examinations were crucial for diagnosis.
- A potential fungal entry point was identified as an oroantral communication.
Findings:
- The patient was diagnosed with sinus aspergillosis.
- The condition's origin was linked to a root canal procedure on a third upper molar.
- Penetration of root canal material may have facilitated fungal entry via oroantral communication.
Implications:
- This case highlights a potential iatrogenic cause of sinus aspergillosis in healthy individuals.
- It underscores the importance of considering dental procedures as a risk factor.
- Accurate diagnosis requires integrating radiological, histological, and clinical findings, especially in refractory sinusitis cases.
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