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Cytochromes P450 in fungi
1Department of Anti-infectives Research, Janssen Research Foundation, Beerse, Belgium.
Mycoses
|August 26, 1998
Abstract:
The article gives an overview on the history of the discovery of P450 cytochromes and on their occurrence in nature, especially on their interactions with metabolic pathways in fungi. The significance of the P450 cytochromes in the ergosterol synthesis as well as in the inhibitory mechanisms caused by imidazole and triazole antimycotics is described in detail.