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Red-cell aggregation and red-cell deformability in diabetes

H Schmid-Schönbein, E Volger

    Diabetes
    |January 1, 1976
    PubMed
    Summary
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    Diabetic blood viscosity anomalies stem from increased plasma viscosity, red-cell aggregation, and reduced cell deformability, impacting microangiopathy development.

    Area of Science:

    • Hematology
    • Diabetology
    • Biophysics

    Background:

    • Human blood viscosity anomalies are exacerbated in diabetic patients.
    • These anomalies are linked to increased plasma viscosity, heightened red blood cell aggregation, and diminished red blood cell deformability.

    Purpose of the Study:

    • To investigate the hemorrheologic factors contributing to blood viscosity anomalies in diabetes.
    • To explore the relationship between plasma protein abnormalities, red blood cell behavior, and microangiopathy in diabetic individuals.

    Main Methods:

    • Analysis of blood viscosity parameters in diabetic and non-diabetic subjects.
    • Assessment of red blood cell aggregation and deformability.
    • Evaluation of plasma protein composition and its correlation with hemorrheologic changes.

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    Main Results:

    • Diabetics exhibit significantly higher plasma viscosity, red blood cell aggregation, and lower red blood cell deformability compared to controls.
    • Abnormal plasma proteins are identified as a primary cause of increased viscosity and aggregation, largely independent of disease duration or metabolic state.
    • Decreased red blood cell deformability is critically dependent on the metabolic control in diabetic patients.

    Conclusions:

    • Hemorrheologic factors, including altered blood viscosity and red blood cell properties, play a significant role in the pathogenesis of diabetic complications.
    • Abnormal plasma proteins and metabolic control are key determinants of these hemorrheologic changes, potentially contributing to microangiopathy development.