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Related Experiment Videos

Screening digital rectal examination and prostate cancer mortality: a case-control study

K E Richert-Boe1, L L Humphrey, A G Glass

  • 1Section of Hematology and Medical Oncology, Department of Veterans Affairs Medical Center, Oregon Health Sciences University, Portland, USA.

Journal of Medical Screening
|August 27, 1998
PubMed
Summary

Digital rectal examination (DRE) is a common prostate cancer screening method, but this study found it does not significantly reduce prostate cancer mortality. Further research may be needed to confirm these findings.

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Area of Science:

  • Urology
  • Oncology
  • Preventive Medicine

Background:

  • Prostate cancer is a leading cause of cancer death in US men.
  • Digital rectal examination (DRE) is a widely used but unproven screening tool for prostate cancer.

Purpose of the Study:

  • To evaluate the effectiveness of screening digital rectal examination (DRE) in reducing prostate cancer mortality.
  • To assess the association between DRE screening and fatal prostate cancer outcomes.

Main Methods:

  • A case-control study was conducted using data from a large health maintenance organization.
  • 150 men with fatal prostate cancer and 299 age-matched controls were analyzed.
  • Screening DRE history within 10 years of diagnosis was determined from medical records.

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Main Results:

  • No significant difference in DRE screening history was observed between men who died from prostate cancer and controls (OR=0.84, 95% CI: 0.48-1.46).
  • Results remained consistent when using a 5-year screening interval or excluding men with benign prostatic hypertrophy.

Conclusions:

  • Screening digital rectal examination (DRE) does not appear to significantly reduce prostate cancer mortality.
  • The current data suggest limited effectiveness of DRE as a standalone screening tool for reducing prostate cancer deaths.