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Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample
S B Manuck1, J D Flory, J M McCaffery
1Behavioral Physiology Laboratory, University of Pittsburgh, Center for Clinical Pharmacology, PA 15260, USA.
Summary
This study found that lower central serotonergic system function in men is linked to higher aggression and impulsivity. These findings suggest a basic neurobehavioral link between serotonin and these traits in the general population.
Area of Science:
- Neuroscience
- Psychology
- Behavioral Science
Background:
- Central serotonergic system function is implicated in behavioral regulation.
- Previous research suggests links between serotonergic activity and aggression/impulsivity, often in clinical populations.
Purpose of the Study:
- To investigate the correlation between central serotonergic system function and aggression/impulsivity traits in a nonpatient population.
- To extend previous findings to a broader range of population variability.
Main Methods:
- A community sample of 119 men and women underwent a fenfluramine challenge test to assess serotonergic responsivity.
- Behavioral measurements, including an aggression interview and the Barratt Impulsiveness Scale, were administered.
- Personality traits were assessed using the NEO-Personality Inventory.
Main Results:
- In men, peak prolactin responses to fenfluramine negatively correlated with aggression history (r = -.40) and impulsivity (r = -.30).
- Serotonergic function also correlated with personality traits in men, including Conscientiousness (r = +.30), Neuroticism (r = -.31), and Angry Hostility (r = -.35).
- No significant relationships were found in women overall, but postmenopausal women showed similar patterns to men.
Conclusions:
- The study supports the hypothesis that lower central serotonergic system function is associated with increased aggression and impulsivity in men.
- These associations may represent a fundamental neurobehavioral dimension of individual differences.
- Further research is needed to explore these relationships, particularly in women and across different age groups.