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Intestinal neuronal dysplasia

P Puri1, T Wester

  • 1Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland.

Seminars in Pediatric Surgery
|August 27, 1998
PubMed
Summary
This summary is machine-generated.

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Intestinal neuronal dysplasia (IND) is an enteric nervous system disorder. Recent techniques confirm IND as a distinct entity, often treatable with conservative methods.

Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Histopathology

Background:

  • Intestinal neuronal dysplasia (IND) is a rare disorder affecting the enteric nervous system.
  • It can occur independently or alongside Hirschsprung's disease.
  • The incidence of isolated IND is uncertain due to diagnostic criterion ambiguity.

Purpose of the Study:

  • To clarify the diagnostic criteria for Intestinal neuronal dysplasia (IND).
  • To establish IND as a distinct histopathologic entity.
  • To outline current treatment strategies for IND.

Main Methods:

  • Review of literature concerning diagnostic criteria, biopsy procedures, and staining techniques for IND.
  • Application of histochemical and immunohistochemical techniques to identify IND.

Related Experiment Videos

  • Analysis of patient age variability in diagnostic approaches.

    • Main Results:

    • Recent application of histochemical and immunohistochemical techniques confirms IND as a distinct histopathologic entity.
    • Diagnostic difficulties stem from variability in criteria, procedures, and techniques.
    • The majority of IND cases respond to conservative management.

    Conclusions:

    • Intestinal neuronal dysplasia is a definable histopathologic entity.
    • Conservative treatment with laxatives and enemas is effective for most patients.
    • Internal sphincter myectomy is a viable option for persistent symptoms after conservative therapy.