Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoganglionosis

A F Schärli1, R Sossai

  • 1Department of Pediatric Surgery, Children's Hospital, Lucerne, Switzerland.

Seminars in Pediatric Surgery
|August 27, 1998
PubMed
Summary
This summary is machine-generated.

Intestinal hypoganglionosis (H) presents diagnostic challenges, often mimicking Hirschsprung's disease. Improved diagnostic methods are crucial for identifying H, leading to better patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Esophageal reconstruction by elongation of the lesser gastric curvature.

Pediatric surgery international·2013
Same author

Animal research in pediatric surgery : Editorial.

Pediatric surgery international·2013
Same author

Congenital diaphragmatic hernia: an ongoing debate : Editorial.

Pediatric surgery international·2013
Same author

Greenstick fractures of the middle third of the forearm. A prospective multi-centre study.

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie·2010
Same author

Updated results on intestinal neuronal dysplasia (IND B).

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie·2005
Same author

New pathogenetic aspects of gut dysmotility in aplastic and hypoplastic desmosis of early childhood.

Pediatric surgery international·2001
Same journal

The EXTra-uterine Environment for Neonatal Development (EXTEND) - future treatment for prematurity and potentially other congenital disease.

Seminars in pediatric surgery·2026
Same journal

Appendicitis as a model for pediatric surgical quality improvement and standardization.

Seminars in pediatric surgery·2026
Same journal

From FOB to PICU: military trauma systems that changed pediatrics.

Seminars in pediatric surgery·2026
Same journal

Long-term follow-up after surgery for congenital anomalies: A time to complication analysis.

Seminars in pediatric surgery·2026
Same journal

Radio-surgical decision-making in hepatoblastoma in the post-PHITT era: SIOPEL consensus recommendations.

Seminars in pediatric surgery·2026
Same journal

Seminars in pediatric sugery pediatric metabolic and bariatric surgery.

Seminars in pediatric surgery·2026
See all related articles

Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Histopathology

Background:

  • Intestinal hypoganglionosis (H) is rarely reported due to diagnostic difficulties.
  • Symptoms like persistent stool retention and colonic distension overlap with Hirschsprung's disease.
  • Histochemical diagnosis is challenging without full-thickness biopsies.

Purpose of the Study:

  • To highlight the diagnostic challenges and findings associated with intestinal hypoganglionosis.
  • To review the clinical presentation, diagnosis, and management of H.
  • To emphasize the importance of morphometric examination for confirming H.

Main Methods:

  • Review of 353 rectal biopsies to identify cases of H.
  • Morphometric examination of ganglion cell number and nerve fiber development.

Related Experiment Videos

  • Analysis of clinical presentation, diagnostic methods, and treatment outcomes.

    • Main Results:

    • 15 cases of H were detected among 353 rectal biopsies.
    • H occurred in isolated forms, combined with distal aganglionosis, or with proximal intestinal neuronal dysplasia.
    • Surgical resection and pull-through procedures yielded good outcomes for localized H.
    • Disseminated H in the small bowel and colon led to dependence on parenteral feeding in two patients.

    Conclusions:

    • Morphometric examination is essential for diagnosing intestinal hypoganglionosis.
    • Improved diagnostic measures are expected to increase H diagnoses.
    • Early and accurate diagnosis is critical for appropriate management and improved patient outcomes.