Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Chronic myeloproliferative diseases]

L Sréter1

  • 1Semmelweis Orvostudományi Egyetem, Budapest.

Orvosi Hetilap
|August 27, 1998
PubMed
Summary
This summary is machine-generated.

Chronic myeloproliferative diseases are bone marrow stem cell disorders characterized by excess blood cell production. Advances in treating chronic myelogenous leukemia include bone marrow transplantation and interferon therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity of the notch-signalling pathway in circulating human chronic lymphocytic leukaemia cells.

Scandinavian journal of immunology·2007
Same author

Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research·2001
Same author

Detection of a b3a3 type chimera in chronic myeloid leukemia by double hybridisation of RT-PCR products.

Haematologia·2000
Same author

[The role of nutrition in the pathogenesis and prevention of oncologic diseases].

Orvosi hetilap·1999
Same author

[Serologic study of human herpesviruses 6 and 7 in lymphoma patients].

Orvosi hetilap·1999
Same author

Automated prozone effect detection in ferritin homogeneous immunoassays using neural network classifiers.

Clinical chemistry and laboratory medicine·1999

Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Biology

Background:

  • Chronic myeloproliferative diseases (CMPDs) are a group of bone marrow stem cell disorders.
  • Characterized by the overproduction of one or more blood cell types.
  • Key CMPDs include chronic myelogenous leukemia, polycythemia rubra vera, osteomyelosclerosis/agnogenic myeloid metaplasia, and essential thrombocythemia.

Purpose of the Study:

  • To provide an overview of chronic myeloproliferative diseases.
  • To discuss their characteristics, clinical findings, and transformations.
  • To highlight therapeutic advancements in CMPDs.

Main Methods:

  • Review of the pathophysiology of CMPDs.
  • Description of characteristic clinical findings like splenomegaly and bone marrow transformation.

Related Experiment Videos

  • Summary of current and emerging therapeutic strategies.

    • Main Results:

    • Abnormal control of cell division leads to excess blood cell accumulation.
    • Bone marrow fibrosis and extramedullary hematopoiesis are common.
    • Significant therapeutic progress has been made, particularly for chronic myelogenous leukemia.

    Conclusions:

    • CMPDs are heterogeneous stem cell disorders with shared features.
    • Therapeutic options like bone marrow transplantation and interferon are established for certain CMPDs.
    • New agents such as anagrelide show promise for myeloproliferative thrombocytosis.