Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolution by nearly-neutral mutations

T Ohta1

  • 1National Institute of Genetics, Shizuoka-ken, Japan.

Genetica
|August 28, 1998
PubMed
Summary
This summary is machine-generated.

Genetic systems exhibit complex interactions. Simulations reveal numerous nearly-neutral mutations, with evolution speed depending on population size and random genetic drift, impacting novel system attainment and extinction risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1.

Gene·1992
Same author

Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes.

Carcinogenesis·1992
Same author

Isolation of 2 novel RFLP markers and their localization at 2q35 by microdissection and subsequent enzymatic amplification.

The Japanese journal of human genetics·1992
Same author

Sensitive period for the induction of endoreduplication by rotenone in cultured Chinese hamster cells.

Chromosoma·1992
Same author

Russuphelin A, a new cytotoxic substance from the mushroom Russula subnigricans Hongo.

Chemical & pharmaceutical bulletin·1992
Same author

Argyrophilic nucleolar organizer region counts in exocrine pancreatic tumors.

International journal of pancreatology : official journal of the International Association of Pancreatology·1992
Same journal

Morphological and COI-based identification of species of the Hawkmoth genus Theretra Hübner, 1819 (Lepidoptera: Sphingidae) from Himachal Pradesh, India.

Genetica·2026
Same journal

Advancing genetics and evolution: new Editors-in-Chief in Genetica.

Genetica·2026
Same journal

Origin and diversification of Altai osmans (Oreoleuciscus), Far Eastern phoxinin minnows (Rhynchocypris) and Far Eastern redfins (Tribolodon) of the Leuciscidae family (Actinopterygii): an example of evolutionary tempo variation?

Genetica·2026
Same journal

Chloroplast genome comparison, phylogeny, and molecular evolution of five endemic Potentilla (Rosaceae) species in Mongolia.

Genetica·2026
Same journal

Severe trauma and chronic stress: seeds and fruits of epigenetic sensitivity.

Genetica·2026
Same journal

Molecular evolution and antigenic mapping of classical swine fever virus: a comprehensive analysis of E2 genomic variability and selection dynamics.

Genetica·2026
See all related articles

Area of Science:

  • Evolutionary biology
  • Systems genetics
  • Computational biology

Background:

  • Genetic systems involve intricate interactions at multiple levels, including amino acids, gene products, and regulatory elements.
  • Mammalian gene substitution patterns suggest that nonsynonymous substitutions are largely neutral due to amino acid interactions.

Purpose of the Study:

  • To analyze the NK model of Kauffman as a representation of interactive genetic systems.
  • To investigate the dynamics of evolution, mutation, and selection in complex genetic landscapes.

Main Methods:

  • Analysis of the NK model, where each amino acid's fitness contribution depends on itself and K other amino acids.
  • Computational simulations to explore evolutionary trajectories on rugged fitness landscapes.

Related Experiment Videos

Main Results:

  • Identified numerous nearly-neutral mutations within the simulated genetic system.
  • Demonstrated that evolutionary rates are rapid in small populations and slow in large populations.
  • Observed that random genetic drift significantly influences the attainment of novel genetic systems, particularly in smaller populations.

Conclusions:

  • Complex genetic systems harbor many nearly-neutral mutations.
  • Population size critically affects evolutionary speed and the likelihood of discovering new genetic systems.
  • While small populations have a higher chance of innovation, they also face increased extinction risks due to stronger genetic drift.