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Related Experiment Videos

Adaptive mutagenesis: a process that generates almost exclusively beneficial mutations

B G Hall1

  • 1Biology Department, University of Rochester, NY 14627, USA. drbh@uhura.cc.rochester.edu

Genetica
|August 28, 1998
PubMed
Summary

Adaptive mutations are stress-induced changes in microorganisms. This review explores evidence for adaptive mutagenesis, highlighting its specificity to environmental challenges and discussing relevant genes and evolutionary roles.

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Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Genetics

Background:

  • Adaptive mutations arise in microorganisms under prolonged stress in non-dividing populations.
  • These mutations are specific to the environmental stressor.
  • This review examines literature on adaptive mutagenesis published since 1993.

Purpose of the Study:

  • To review and assess the evidence for adaptive mutagenesis.
  • To investigate the specificity of adaptive mutations.
  • To discuss genetic factors, models, and implications of adaptive mutagenesis.

Main Methods:

  • Literature review of studies on adaptive mutagenesis since 1993.
  • Critical analysis of experimental systems used to study adaptive mutagenesis.
  • Discussion of genetic evidence and proposed models.

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Main Results:

  • Evidence for adaptive mutagenesis as a real and general phenomenon is considered.
  • The commonly used F'-borne lacI33 allele system is identified as a special case, potentially influenced by F-plasmid biology.
  • New evidence supporting the specificity of adaptive mutagenesis to environmental challenges is presented.

Conclusions:

  • Adaptive mutagenesis is a specific response to environmental stress, not a general phenomenon.
  • Specific genes influence the rate and nature of adaptive mutagenesis.
  • Understanding adaptive mutagenesis has implications for evolution and practical applications.