Anti-platelet aggregation constituents from Formosan Toddalia asiatica

Area of Science:

• Phytochemistry
• Pharmacology

Background:

• Formosan Toddalia asiatica is a plant source of bioactive natural products.
• Natural products are crucial for drug discovery and development.

Purpose of the Study:

• To isolate and characterize compounds from the wood of Formosan Toddalia asiatica.
• To evaluate the isolated compounds for anti-platelet aggregation activity.

Main Methods:

• Phytochemical investigation involving isolation and structure elucidation of compounds using spectroscopic data and chemical evidence.
• Bioassay-guided fractionation to identify active compounds.
• In vitro anti-platelet aggregation assays.

Main Results:

• Thirty compounds were isolated, including coumarins, alkaloids, a benzoquinone, and an amine.
• Two new compounds, (+/-)-toddanin and (-)-isocoreximine, were identified.
• Cyclohexylamine was isolated from a natural source for the first time.
• Seven compounds exhibited strong in vitro anti-platelet aggregation activity.

Conclusions:

• The wood of Formosan Toddalia asiatica is a rich source of diverse chemical compounds.
• Several isolated compounds possess significant potential for anti-platelet aggregation therapy.
• Further research into these compounds could lead to novel anti-thrombotic agents.