Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antidepressant response in late-life depression

S P Roose1, K M Suthers

  • 1Department of Psychiatry, Late Life Depression Research Clinic, New York State Psychiatric Institute, Columbia University, New York 10032, USA.

The Journal of Clinical Psychiatry
|August 28, 1998
PubMed
Summary

Evaluating late-life depression treatment requires rigorous methodology. Nortriptyline shows high remission rates (70-80%), while SSRIs like fluoxetine and sertraline vary, with tricyclics not increasing dropout but potentially impacting quality of life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized, prospective pilot study of patient expectancy and antidepressant outcome.

Psychological medicine·2012
Same author

Current psychotherapy research methodology applied to psychoanalysis : a feasibility study.

The Journal of psychotherapy practice and research·2012
Same author

Depression and comorbid medical disorders: a reversal of causality.

CNS spectrums·2008
Same author

Quality of life, mood, and sexual function: a path analytic model of treatment effects in men with erectile dysfunction and depressive symptoms.

International journal of impotence research·2004
Same author

Depression in the long-term care patient: new tools for evaluation and treatment.

Journal of the American Medical Directors Association·2003
Same author

Depression, anxiety, and the cardiovascular system: the psychiatrist's perspective.

The Journal of clinical psychiatry·2002

Area of Science:

  • Geriatric Psychiatry
  • Pharmacological Treatments
  • Clinical Trial Methodology

Background:

  • Late-life depression treatment efficacy is debated.
  • Methodological rigor is crucial for interpreting antidepressant study results.
  • Antidepressant selection requires careful consideration of remission rates and side effect profiles.

Purpose of the Study:

  • To critically evaluate the literature on antidepressant treatments for late-life depression.
  • To assess the impact of methodological standards on reported treatment outcomes.
  • To compare the efficacy and tolerability of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) in older adults.

Main Methods:

  • Systematic review of studies on late-life depression treatment.

Related Experiment Videos

  • Inclusion criteria focused on rigorous methodology: adequate dosing duration, clear remission criteria, and intent-to-treat/completer analyses.
  • Comparison of remission rates and dropout rates between TCAs and SSRIs.

    • Main Results:

    • Therapeutic nortriptyline levels achieved 70-80% remission rates in patients over 60.
    • Fluoxetine remission rates ranged from 21% to 50%; sertraline consistently showed 50% or higher.
    • Tricyclic antidepressant treatment did not result in higher dropout rates compared to SSRIs.

    Conclusions:

    • Rigorous methodology in late-life depression studies reveals consistent efficacy for nortriptyline.
    • While TCAs are not associated with higher dropout, their side effects may negatively impact long-term quality of life.
    • SSRIs demonstrate variable efficacy, necessitating further research into optimal treatment selection for older adults.