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Primary cutaneous T-cell lymphoma involving the cheek: an infant case with a unique clinicopathologic feature
M Imaizumi1, R Ichinohasama, A Sato
1Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan. mimaizumi@ped.med.tohoku.ac.jp
Insights
A rare case of childhood cutaneous T-cell lymphoma (CTCL) in a young boy showed atypical lymphoid cells. Treatment with interferon-alpha and steroids led to prolonged remission, offering insights into pediatric CTCL.
Area of Science:
- Dermatology
- Pediatric Oncology
- Hematology
Background:
- Primary cutaneous T-cell lymphoma (CTCL) is rare in children.
- Understanding pediatric CTCL clinicopathologic features is crucial for effective treatment.
Observation:
- A five-year-old boy presented with cheek swelling, diagnosed as primary cutaneous T-cell lymphoma.
- Histopathology revealed atypical lymphoid cells with mature T-cell phenotype and clonality in dermal and subcutaneous tissues.
Findings:
- Aggressive multidrug chemotherapy showed limited efficacy.
- Interferon-alpha and steroid therapy resulted in a prolonged remission.
Implications:
- This case highlights a potential therapeutic strategy for pediatric CTCL.
- Further research into rare pediatric CTCL presentations is warranted.
- This case offers valuable insights into the clinicopathologic features of rare primary CTCL in young children.
Abstract:
We report a clinicopathologic feature of primary cutaneous T-cell lymphoma (CTCL) in a five-year-old boy with increasing swelling of his cheek since two years of age. Histologically, an infiltrate of atypical lymphoid cells with mature T-cell phenotype and clonality was prominent from the dermis to the subcutaneous tissue of the cheek. Although little effect was seen with aggressive multidrug-combined chemotherapy, therapy with interferon-alpha and steroids achieved a prolonged remission. This patient may provide important clues to understanding the clinicopathologic feature of rare primary CTCL in young children.