Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Death receptors: signaling and modulation

A Ashkenazi1, V M Dixit

  • 1Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. aa@gene.com

Science (New York, N.Y.)
|August 28, 1998
PubMed
Summary

Apoptosis, a programmed cell death, is vital for animal survival. Specialized cell surface death receptors detect external signals, triggering internal apoptosis pathways to eliminate harmful cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inclusive Search for Anomalous Single-Photon Production in MicroBooNE.

Physical review letters·2026
Same author

First Search for Dark Sector e^{+}e^{-} Explanations of the MiniBooNE Anomaly at MicroBooNE.

Physical review letters·2026
Same author

First Measurement of Charged-Current Muon-Neutrino-Induced K^{+} Production on Argon Using the MicroBooNE Detector.

Physical review letters·2026
Same author

Correction: TRAF2 is a biologically important necroptosis suppressor.

Cell death and differentiation·2025
Same author

Search for an Anomalous Production of Charged-Current ν_{e} Interactions without Visible Pions across Multiple Kinematic Observables in MicroBooNE.

Physical review letters·2025
Same author

First Measurement of ν_{e} and ν[over ¯]_{e} Charged-Current Single Charged-Pion Production Differential Cross Sections on Argon Using the MicroBooNE Detector.

Physical review letters·2025

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Immunology

Background:

  • Apoptosis is a fundamental biological process for multicellular organisms.
  • It plays a critical role in tissue homeostasis and development.
  • Dysregulation of apoptosis is implicated in various diseases.

Purpose of the Study:

  • To elucidate the role of death receptors in initiating apoptosis.
  • To understand how extracellular signals trigger programmed cell death.
  • To explore the mechanisms of the intrinsic apoptosis pathway.

Main Methods:

  • Investigated cell surface death receptors.
  • Analyzed the detection of extracellular death signals.
  • Examined the activation of the intrinsic apoptosis machinery.

Main Results:

  • Identified specific cell surface sensors as death receptors.
  • Demonstrated that death receptors detect extracellular death signals.
  • Confirmed that death receptors trigger the intrinsic apoptosis pathway.

Conclusions:

  • Death receptors are key initiators of the apoptosis cascade.
  • Extracellular signals mediated by death receptors are crucial for cell survival control.
  • The intrinsic apoptosis machinery is rapidly activated upon death receptor signaling.

Related Experiment Videos