Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondria and apoptosis

D R Green1, J C Reed

  • 1La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.

Science (New York, N.Y.)
|August 28, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibody profiling of a Borreliella burgdorferi (Lyme disease) C6 antibody positive, symptomatic Rottweiler and her pups.

Veterinary journal (London, England : 1997)·2020
Same author

Carmine Melino.

Annali di igiene : medicina preventiva e di comunita·2017
Same author

Caspase-2-mediated cell death is required for deleting aneuploid cells.

Oncogene·2016
Same author

Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.

Molecular psychiatry·2016
Same author

Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.

Mucosal immunology·2016
Same author

The clearance of dying cells: table for two.

Cell death and differentiation·2016
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
See all related articles

Mitochondria play a central role in apoptosis, regulating cell death through events like caspase release and potential changes. Understanding these mitochondrial pathways is key to deciphering physiological cell death mechanisms.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Apoptosis, or programmed cell death, is crucial for development and tissue homeostasis.
  • Mitochondria are central regulators of the intrinsic apoptosis pathway.
  • Key mitochondrial events include cytochrome c release and loss of mitochondrial membrane potential.

Purpose of the Study:

  • To elucidate the multifaceted roles of mitochondria in initiating and regulating apoptosis.
  • To detail the signaling pathways converging on mitochondria during programmed cell death.

Main Methods:

  • Analysis of mitochondrial events during apoptosis.
  • Investigation of pro- and antiapoptotic Bcl-2 family protein involvement.
  • Examination of signaling pathways influencing mitochondrial function in cell death.

Related Experiment Videos

Main Results:

  • Mitochondria orchestrate critical apoptosis events, including caspase activator release and altered bioenergetics.
  • Mitochondrial transmembrane potential dissipation is a key indicator of apoptosis.
  • Bcl-2 family proteins modulate mitochondrial apoptosis pathways.

Conclusions:

  • Mitochondria are pivotal in executing physiological cell death.
  • Distinct signaling cascades converge on mitochondria to control apoptosis.
  • Understanding mitochondrial roles in apoptosis is vital for therapeutic strategies.