Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Stress, adaptation, and nitric oxide

I Y Malyshev¹, E B Manukhina

¹Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, 125315, Russia. nii@pathophys.msk.ru

Biochemistry. Biokhimiia

|August 29, 1998

Summary

Nitric oxide (NO) is a crucial regulator of physiological functions and stress responses. This review highlights NO

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Role of Preoperative Stress in Myocardial Injury during Noncardiac Surgery in Wistar Rats.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2025

Same author

Age Specifics of Homeostasis Response to Cold Stress in Wistar Rats: Endurance Improvement or Disorganization?

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2024

Same author

Erratum to: "Anxiety and neurometabolite levels in the hippocampus and amygdala after prolonged exposure to predator-scent stress".

Vavilovskii zhurnal genetiki i selektsii·2021

Same author

[Cellular and molecular mechanisms of inflammation of esophageal mucosa under different clinical course of gastroesophageal reflux disease and its complications].

Terapevticheskii arkhiv·2020

Same author

Physical Fatigue and Morphofunctional State of the Myocardium in Experimental Chronic Stress.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2019

Same author

[Effect of adaptation to hypoxia on expression of NO synthase isoforms in rat myocardium].

Patologicheskaia fiziologiia i eksperimental'naia terapiia·2016

Area of Science:

Physiology
Molecular Biology
Biochemistry

Background:

Nitric oxide (NO) is increasingly recognized for its regulatory roles in physiology and metabolism.
Research continues to uncover NO's involvement in gene expression and protein biosynthesis.

Purpose of the Study:

To review the biological role of nitric oxide (NO) in stress and adaptive responses.
To highlight NO generation as a novel stress-limiting system.

Main Methods:

Literature review of molecular biology and physiological studies.
Analysis of NO's role across different stages of adaptation.

Main Results:

NO plays a significant role in stress reactions and adaptive mechanisms.
The NO-ergic system limits stress responses and enhances endogenous defenses.
NO influences urgent, transitional, and long-term adaptation stages.

Conclusions:

The NO generation system is a newly discovered mechanism for limiting stress.
Pharmacological NO donors can protect against stress damage and improve adaptive capacity.

Related Experiment Videos