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Liposome-DNA interaction: microcalorimetric study
G M Mrevlishvili1, B I Kankia, T J Mdzinarashvili
1Department of Physics, Tbilisi State University, Georgia.
Chemistry and Physics of Lipids
|August 29, 1998
Abstract:
The authors applied differential scanning calorimetry (DSC) for studying the thermodynamic characteristics of DNA-liposome interactions. At the first stage, the melting curves of the 'order-disorder' thermal transition for lipid component and of the 'helix-coil' transition for DNA were obtained. At the second stage, the phase behavior of the DNA-lipid mixture as a function of both components (lipid/DNA ratio) was obtained. The liposome-DNA interaction was investigated comparing the melting curves of the pure components and the mixture.